MYCN: from oncoprotein to tumor-associated antigen
نویسندگان
چکیده
منابع مشابه
MYCN: from oncoprotein to tumor-associated antigen
MYCN is a well-known oncogene over-expressed in different human malignancies including neuroblastoma (NB), rhabdomyosarcoma, medulloblastoma, astrocytoma, Wilms' tumor, and small cell lung cancer. In the case of NB, MYCN amplification is an established biomarker of poor-prognosis. MYCN belongs to a family of transcription factors (the most important of which is C-MYC) that show a high degree of...
متن کاملOncoprotein hides tumor
An oncogenic fusion protein hijacks a transcription factor, and uses it to help its tumor avoid immune detection, according to a study by Nabarro and colleagues on page 1399. This is the first description of an oncoprotein that can both transform cells and shut down the immune response. The protein, PAX3-FKHR, results from a reciprocal chromosomal translocation in a rare form of a childhood mus...
متن کاملConstruction of phosphorylatable monoclonal antibody to a tumor-associated antigen.
A phosphorylation site was introduced into chimeric monoclonal antibody B72.3 (MAb-chB72.3) by site-specific mutation of the coding sequence. The phosphorylation site for the cAMP-dependent protein kinase was positioned at the carboxyl terminus of the heavy-chain constant region of MAb-chB72.3. The resultant modified MAb-chB72.3-P was expressed in 293 cells and purified. The MAb-chB72.3-P prote...
متن کاملTumor associated antigen in ovarian carcinoma.
Tumor associated antigen present in the cyst fluid of a patient with papillary mucinous cytadenocarcinoma of the ovary was prepared by ammonium sulfate precipitation. The dialyzed precipitate was emulsified in complete Freund's adjuvant and injected into rabbits followed by booster doses of the antigen in saline. The resulting antiserum was absorbed with normal human serum and normal liver and ...
متن کاملIdentification of Pancreatic Cancer-Associated Tumor Antigen from HSP-Enriched Tumor Lysate-Pulsed Human Dendritic Cells
PURPOSE Vaccine strategies utilizing dendritic cells (DCs) to elicit anti-tumor immunity are the subject of intense research. Although we have shown that DCs pulsed with heat-treated tumor lysate (HTL) induced more potent anti-tumor immunity than DCs pulsed with conventional tumor lysate (TL), the underlying molecular mechanism is unclear. In order to explore the molecular basis of this approac...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2012
ISSN: 2234-943X
DOI: 10.3389/fonc.2012.00174